Identification of a Methioninase Inhibitor, Myrsinoic Acid B, from Myrsine seguinii Lév., and Its Inhibitory Activities

Abstract

A methioninase inhibitor from Myrsine seguinii was purified and identified as myrsinoic acid B. Its inhibitory activities as to crude methioninase from periodontal bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola were determined. The IC₅₀ values were 10.5, 82.4, and 30.3 μM respectively.