Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans

Koichi AKIYAMA; Satoshi YAMAUCHI; Masafumi MARUYAMA; Takuya SUGAHARA; Taro KISHIDA; Yojiro KOBA

doi:10.1271/bbb.80536

Organic Chemistry Regular Papers

Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans

Koichi AKIYAMA, Satoshi YAMAUCHI, Masafumi MARUYAMA, Takuya SUGAHARA, Taro KISHIDA, Yojiro KOBA

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Keywords: neolignan, tetrahydropyran neolignan, antimicrobial activity

JOURNAL FREE ACCESS

2009 Volume 73 Issue 1 Pages 129-133

DOI https://doi.org/10.1271/bbb.80536

View "Advance Publication" version (January 7, 2009).

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Abstract

The antimicrobial activity of all stereoisomers of morinols A and B was tested. All stereoisomers of morinols A and B showed antifungal activity against Alternaria alternata, especially (−)-morinol B which showed the strongest activity. The natural component, (+)-morinol A, and unnatural stereoisomer, (7S,7′S,8R,8′R)-morinol B, showed antibacterial activity against the gram-positive bacteria, Bacillus subtilis and Listeria denitrificans.

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