Dietary Resistant Starch Reduces Histone Acetylation on the Glucose-Dependent Insulinotropic Polypeptide Gene in the Jejunum

Masaya SHIMADA; Kazuki MOCHIZUKI; Toshinao GODA

doi:10.1271/bbb.90384

Food & Nutrition Science Notes

Dietary Resistant Starch Reduces Histone Acetylation on the Glucose-Dependent Insulinotropic Polypeptide Gene in the Jejunum

Masaya SHIMADA, Kazuki MOCHIZUKI, Toshinao GODA

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Keywords: resistant starch, glucose-dependent insulinotropic polypeptide, histone acetylation, chromatin, small intestine

JOURNAL FREE ACCESS

2009 Volume 73 Issue 12 Pages 2754-2757

DOI https://doi.org/10.1271/bbb.90384

View "Advance Publication" version (December 7, 2009).

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Abstract

We have reported that dietary resistant starch (RS) reduces glucose-dependent insulinotropic polypeptide (GIP) mRNA levels along the jejunoileum in both normal and diabetic rats. In this study, we found that jejunal reduction of the GIP gene by feeding normal rats dietary RS was associated with decreases in histone H3 and H4 acetylation on the promoter/enhancer region of the gene.

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