Taxusecone, a Novel Taxane with an Unprecedented 11,12-Secotaxane Skeleton, from Taxus cuspidata Needles

Shu-Hong YU; Zhi-Yu NI; Jing ZHANG; Mei DONG; Françoise SAURIOL; Chang-Hong HUO; Qing-Wen SHI; Yu-Cheng GU; Hiromasa KIYOTA; Bin CONG

doi:10.1271/bbb.80698

Organic Chemistry Notes

Taxusecone, a Novel Taxane with an Unprecedented 11,12-Secotaxane Skeleton, from Taxus cuspidata Needles

Shu-Hong YU, Zhi-Yu NI, Jing ZHANG, Mei DONG, Françoise SAURIOL, Chang-Hong HUO, Qing-Wen SHI, Yu-Cheng GU, Hiromasa KIYOTA, Bin CONG

Author information

Shu-Hong YU
Schools of Pharmaceutical Sciences, Hebei Medical University
Zhi-Yu NI
Department of Forensic Medicine, Hebei Medical University
Jing ZHANG
The Third Affiliated Hospital of Hebei Medical University
Mei DONG
Department of Forensic Medicine, Hebei Medical University
Françoise SAURIOL
Department of Chemistry, Queen’s University
Chang-Hong HUO
Schools of Pharmaceutical Sciences, Hebei Medical University
Qing-Wen SHI
Schools of Pharmaceutical Sciences, Hebei Medical University
Yu-Cheng GU
Schools of Pharmaceutical Sciences, Hebei Medical University
Syngenta, Jealott’s Hill International Research Centre
Hiromasa KIYOTA
Graduate School of Agricultural Science, Tohoku University
Bin CONG
Department of Forensic Medicine, Hebei Medical University

Keywords: 11,12-secotaxane, Taxus cuspidata, taxanes, natural products, isolation

JOURNAL FREE ACCESS

2009 Volume 73 Issue 3 Pages 756-758

DOI https://doi.org/10.1271/bbb.80698

View "Advance Publication" version (March 7, 2009).

Details

Abstract

Taxusecone, 2α,7β,9α,10β-tetraacetoxy-5α,12-dihydroxy-11,12-secotax-4(20)-ene-11,13-dione (1), a novel taxane with an unprecedented skeleton, was isolated from the needles of Taxus cuspidata.

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