Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Potent Antioxidative Activity of Vineatrol®30 Grapevine-shoot Extract
Carsten MÜLLERKristina ULLMANNAndrea WILKENSPeter WINTERHALTERShinya TOYOKUNIPablo STEINBERG
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2009 Volume 73 Issue 8 Pages 1831-1836

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Abstract

The health promoting effects of a grapevine-shoot extract named Vineatrol®30, which contains resveratrol (Resv) as well as considerable amounts of Resv oligomers, have recently been investigated. In the present study, we analyzed the free radical scavenging capacity, the ability to inhibit lipid peroxidation, and the capacity to enhance the human glutathione peroxidase 1 (GPx) and the human superoxide dismutase 1 (SOD) gene promoter activities of Vineatrol®30. Vineatrol®30 was able to scavenge the 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical cation and led to concentration-dependent inhibition of lipid peroxidation, Vineatrol®30 not being superior to Resv alone in both cases. Vineatrol®30 also enhanced the gene promoter activities of human GPx and SOD expressed in V79 cells, whereas this effect could not be demonstrated for Resv. In summary, the results presented in this study show that the Vineatrol®30 grapevine-shoot extract is a free radical scavenger and potent antioxidant at non-cytotoxic concentrations.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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