Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice
Kiichiro AKAMINETomoyuki KOYAMAKazunaga YAZAWA
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JOURNALS FREE ACCESS

2009 Volume 73 Issue 9 Pages 1911-1914

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Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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