2010 Volume 74 Issue 2 Pages 415-418
L-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected L-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.
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