Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications

Takeshi ISHII; Mitsugu AKAGAWA; Yuji NAITO; Osamu HANDA; Tomohisa TAKAGI; Taiki MORI; Shigenori KUMAZAWA; Toshikazu YOSHIKAWA; Tsutomu NAKAYAMA

doi:10.1271/bbb.90764

Food & Nutrition Science Notes

Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications

Takeshi ISHII, Mitsugu AKAGAWA, Yuji NAITO, Osamu HANDA, Tomohisa TAKAGI, Taiki MORI, Shigenori KUMAZAWA, Toshikazu YOSHIKAWA, Tsutomu NAKAYAMA

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Keywords: pyrroloquinoline quinone, prooxidant action, protein oxidative modification

JOURNAL FREE ACCESS

2010 Volume 74 Issue 3 Pages 663-666

DOI https://doi.org/10.1271/bbb.90764

View "Advance Publication" version (March 7, 2010).

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Abstract

Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.

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