Synthesis of γ-Lactone-Type Sialic Acid, an Isomer of 2,3-Dehydrosialic Acid

Abstract

An efficient synthesis of γ-lactone-type sialic acid, which is an isomer of 2,3-dehydrosialic acid, was achieved from the corresponding sialic ester. The sialic ester was reconstructed from the γ-lactone in a 95% yield. The γ-lactone structure was determined by methylating to its corresponding methyl ether.