Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

Osamu OHNO; Taeko WATABE; Kazuhiko NAKAMURA; Masaru KAWAGOSHI; Nobuo UOTSU; Tomohiro CHIBA; Masayoshi YAMADA; Kohji YAMAGUCHI; Kaoru YAMADA; Kenji MIYAMOTO; Daisuke UEMURA

doi:10.1271/bbb.100221

Food & Nutrition Science Notes

Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

Osamu OHNO, Taeko WATABE, Kazuhiko NAKAMURA, Masaru KAWAGOSHI, Nobuo UOTSU, Tomohiro CHIBA, Masayoshi YAMADA, Kohji YAMAGUCHI, Kaoru YAMADA, Kenji MIYAMOTO, Daisuke UEMURA

Author information

Keywords: melanin, Piper longum, bakuchiol, bavachin, isobavachalcone

JOURNAL FREE ACCESS

2010 Volume 74 Issue 7 Pages 1504-1506

DOI https://doi.org/10.1271/bbb.100221

View "Advance Publication" version (July 7, 2010).

Details

Abstract

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

Corresponding author

Register with J-STAGE for free!