Disruption of Ion Homeostasis by Verrucosin and a Related Compound

Koichi AKIYAMA; Junichi TONE; Satoshi YAMAUCHI; Takuya SUGAHARA; Masafumi MARUYAMA; Yoshimi KAKINUMA

doi:10.1271/bbb.110004

Biochemistry & Molecular Biology Notes

Disruption of Ion Homeostasis by Verrucosin and a Related Compound

Koichi AKIYAMA, Junichi TONE, Satoshi YAMAUCHI, Takuya SUGAHARA, Masafumi MARUYAMA, Yoshimi KAKINUMA

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Keywords: lignan, verrucosin, ion homeostasis, ionophore

JOURNAL FREE ACCESS

2011 Volume 75 Issue 5 Pages 1000-1002

DOI https://doi.org/10.1271/bbb.110004

View "Advance Publication" version (May 20, 2011).

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Abstract

We have found that (−)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.

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