Citronellol and Geraniol, Components of Rose Oil, Activate Peroxisome Proliferator-Activated Receptor α and γ and Suppress Cyclooxygenase-2 Expression

Michiko KATSUKAWA; Rieko NAKATA; Satomi KOEJI; Kazuyuki HORI; Saori TAKAHASHI; Hiroyasu INOUE

doi:10.1271/bbb.110039

Food & Nutrition Science Notes

Citronellol and Geraniol, Components of Rose Oil, Activate Peroxisome Proliferator-Activated Receptor α and γ and Suppress Cyclooxygenase-2 Expression

Michiko KATSUKAWA, Rieko NAKATA, Satomi KOEJI, Kazuyuki HORI, Saori TAKAHASHI, Hiroyasu INOUE

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Keywords: rose oil, citronellol, geraniol, cyclooxygenase-2 (COX-2), peroxisome proliferator-activated receptor (PPAR)

JOURNAL FREE ACCESS

2011 Volume 75 Issue 5 Pages 1010-1012

DOI https://doi.org/10.1271/bbb.110039

View "Advance Publication" version (May 20, 2011).

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Abstract

We evaluated the effects of rose oil on the peroxisome proliferator-activated receptor (PPAR) and cyclooxygenase-2 (COX-2). Citronellol and geraniol, the major components of rose oil, activated PPARα and γ, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPARγ-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil.

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