Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Note
New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
Yuan QUYang ZHANGLiang PEIYan WANGLijuan GAOQianming HUANGMakoto OJIKAYouji SAKAGAMIJianhua QI
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2011 Volume 75 Issue 6 Pages 1201-1204

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Abstract
A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4′ of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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