New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl

Yuan QU; Yang ZHANG; Liang PEI; Yan WANG; Lijuan GAO; Qianming HUANG; Makoto OJIKA; Youji SAKAGAMI; Jianhua QI

doi:10.1271/bbb.110066

Organic Chemistry Note

New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl

Yuan QU, Yang ZHANG, Liang PEI, Yan WANG, Lijuan GAO, Qianming HUANG, Makoto OJIKA, Youji SAKAGAMI, Jianhua QI

著者情報

キーワード: steroidal saponin, Ophiopogon japonicus, neuritogenic activity, PC12 cells, structure-activity relationship

ジャーナルフリー

2011 年 75 巻 6 号 p. 1201-1204

DOI https://doi.org/10.1271/bbb.110066

View "Advance Publication" version (June 13, 2011).

詳細

抄録

A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4′ of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.

責任著者(Corresponding author)

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