Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Amelioration of D-Galactosamine-Induced Acute Liver Injury in Rats by Dietary Supplementation with Betaine Derived from Sugar Beet Molasses
Tomoko OKADASakura KAWAKAMIYumi NAKAMURAKyu-Ho HANKiyoshi OHBATsutomu ARITSUKAHirokatsu UCHINOKen-ichiro SHIMADAMitsuo SEKIKAWAHiroshi ISHIIMichihiro FUKUSHIMA
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2011 Volume 75 Issue 7 Pages 1335-1341

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Abstract

The effects of betaine supplementation on D-galactosamine-induced liver injury were examined in terms of hepatic and serum enzyme activities and of the levels of glutathione and betaine-derived intermediates. The rats induced with liver injury showed marked increases in serum enzyme activity, but those receiving dietary supplementation of 1% betaine showed enzyme activity levels similar to a control group without liver injury. Administration of betaine also increased both hepatic and serum glutathione levels, even following D-galactosamine injection. The activity of glutathione-related enzymes was markedly decreased following injection of D-galactosamine, but remained comparable to that of the control group in rats receiving 1% betaine. The concentrations of hepatic S-adenosyl methionine and cysteine showed similar trends to that observed for hepatic glutathione levels. These results indicate that 1% betaine has a hepatoprotective effect by increasing hepatic and serum glutathione levels along with glutathione-related enzyme activities in rats.

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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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