Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Regular Papers
Intracellular ATP Levels Affect Secondary Metabolite Production in Streptomyces spp.
Lingzhu MENGMing LISeung Hwan YANGTae-Jong KIMJoo-Won SUH
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JOURNAL FREE ACCESS

2011 Volume 75 Issue 8 Pages 1576-1581

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Abstract

The addition of extracellular ATP (exATP) to four Streptomyces strains had similar effects: low exATP levels stimulated antibiotic production and high levels reduced it. Compared with antibiotic production, the concentrations of intracellular ATP (inATP) in the tested strains were opposite, which suggests a role of inATP in regulating secondary metabolite production. Under inactivation of the polyphosphate kinase gene (ppk) in Streptomyces lividans, we observed the same results: when the inATP level in the mutant strain was lower than in the parent strain, more antibiotic was produced. Combining all the results, a strong inverse relationship between [inATP] and the secondary metabolite production is suggested by this study.

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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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