Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4+T Cells into the Th2 or Th1 Phenotype

Haruyo NAKAJIMA-ADACHI; Emiko KOIKE; Mamoru TOTSUKA; Erika HIRAIDE; Yoshio WAKATSUKI; Hiroshi KIYONO; Satoshi HACHIMURA

doi:10.1271/bbb.120349

Food & Nutrition Science Notes

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype

Haruyo NAKAJIMA-ADACHI, Emiko KOIKE, Mamoru TOTSUKA, Erika HIRAIDE, Yoshio WAKATSUKI, Hiroshi KIYONO, Satoshi HACHIMURA

著者情報

キーワード: OVA323-339 amino acid residue, food allergy, tolerance, oral immunotherapy, epitope

ジャーナルフリー

2012 年 76 巻 10 号 p. 1979-1981

DOI https://doi.org/10.1271/bbb.120349

View "Advance Publication" version (October 7, 2012).

詳細

抄録

The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.

責任著者(Corresponding author)

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