Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Regular Papers
Extension of Chronological Lifespan by ScEcl1 Depends on Mitochondria in Saccharomyces cerevisiae
Kenko AZUMAHokuto OHTSUKAHiroshi MURAKAMIHirofumi AIBA
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JOURNAL FREE ACCESS

2012 Volume 76 Issue 10 Pages 1938-1942

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Abstract

Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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