α-Tocopherol Sensitizes Human Leukemia HL-60 Cells to Apoptosis Induced by Benzyl Isothiocyanate

Naomi ABE; Tomomi SHIMIZU; Noriyuki MIYOSHI; Yoshiyuki MURATA; Yoshimasa NAKAMURA

doi:10.1271/bbb.110665

Food & Nutrition Science Notes

α-Tocopherol Sensitizes Human Leukemia HL-60 Cells to Apoptosis Induced by Benzyl Isothiocyanate

Naomi ABE, Tomomi SHIMIZU, Noriyuki MIYOSHI, Yoshiyuki MURATA, Yoshimasa NAKAMURA

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Keywords: benzyl isothiocyanate, α-tocopherol, apoptosis, caspase-3, HL-60 cells

JOURNAL FREE ACCESS

2012 Volume 76 Issue 2 Pages 381-383

DOI https://doi.org/10.1271/bbb.110665

View "Advance Publication" version (February 7, 2012).

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Abstract

Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

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