Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

Keizo YUASA; Kaori TADA; Genki HARITA; Tomomi FUJIMOTO; Masao TSUKAYAMA; Akihiko TSUJI

doi:10.1271/bbb.110800

Food & Nutrition Science Notes

Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

Keizo YUASA, Kaori TADA, Genki HARITA, Tomomi FUJIMOTO, Masao TSUKAYAMA, Akihiko TSUJI

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Keywords: sudachitin, polymethoxyflavone, anti-inflammation, nitric oxide (NO)

JOURNAL FREE ACCESS

2012 Volume 76 Issue 3 Pages 598-600

DOI https://doi.org/10.1271/bbb.110800

View "Advance Publication" version (March 7, 2012).

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Abstract

Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.

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