Serum Cholesterol Reduction by Feeding a High-Cholesterol Diet Containing a Lower-Molecular-Weight Polyphenol Fraction from Peanut Skin

Tomoko TAMURA; Naoko INOUE; Akiko SHIMIZU-IBUKA; Miki TADAISHI; Toshichika TAKITA; Soichi ARAI; Kiyoshi MURA

doi:10.1271/bbb.110866

Food & Nutrition Science Notes

Serum Cholesterol Reduction by Feeding a High-Cholesterol Diet Containing a Lower-Molecular-Weight Polyphenol Fraction from Peanut Skin

Tomoko TAMURA, Naoko INOUE, Akiko SHIMIZU-IBUKA, Miki TADAISHI, Toshichika TAKITA, Soichi ARAI, Kiyoshi MURA

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Keywords: peanut skin, polyphenol, cholesterol, micelle solubility, bile acid

JOURNAL FREE ACCESS

2012 Volume 76 Issue 4 Pages 834-837

DOI https://doi.org/10.1271/bbb.110866

View "Advance Publication" version (April 7, 2012).

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Abstract

Feeding a high-cholesterol diet with a water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, with an increase in fecal cholesterol excretion. The hypocholesterolemic effect was greater with the lower-molecular-weight rather than higher-molecular-weight polyphenol fraction. This effect was possibly due to some oligomeric polyphenols which reduced the solubility of dietary cholesterol in intestinal bile acid-emulsified micelles.

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