Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α

Hye-Sun SHIN; Seong-Il KANG; Seon-A YOON; Hee-Chul KO; Se-Jae KIM

doi:10.1271/bbb.110908

Food & Nutrition Science Notes

Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α

Hye-Sun SHIN, Seong-Il KANG, Seon-A YOON, Hee-Chul KO, Se-Jae KIM

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Keywords: sinensetin, polymethoxyflavone, inflammation, inhibitor κB-α

JOURNAL FREE ACCESS

2012 Volume 76 Issue 4 Pages 847-849

DOI https://doi.org/10.1271/bbb.110908

View "Advance Publication" version (April 7, 2012).

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Abstract

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C₄ position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

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