New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound

Shigeru NAKAYA; Saki MIZUNO; Hiroki ISHIGAMI; Yasuhiro YAMAKAWA; Hirokazu KAWAGISHI; Takashi USHIMARU

doi:10.1271/bbb.110872

Food & Nutrition Science Notes

New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound

Shigeru NAKAYA, Saki MIZUNO, Hiroki ISHIGAMI, Yasuhiro YAMAKAWA, Hirokazu KAWAGISHI, Takashi USHIMARU

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Keywords: anti-aging, beauveriolide I, budding yeast, Cordyceps militaris

JOURNAL FREE ACCESS

2012 Volume 76 Issue 6 Pages 1226-1228

DOI https://doi.org/10.1271/bbb.110872

View "Advance Publication" version (June 7, 2012).

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Abstract

The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

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