Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

Keiji YUKI; Mariko IKEDA; Kenji MIYAMOTO; Osamu OHNO; Kaoru YAMADA; Daisuke UEMURA

doi:10.1271/bbb.110994

Organic Chemistry Note

Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

Keiji YUKI, Mariko IKEDA, Kenji MIYAMOTO, Osamu OHNO, Kaoru YAMADA, Daisuke UEMURA

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Keywords: Valeriana fauriei, 3T3-L1 murine adipocytes, inhibitor, fat accumulation

JOURNAL FREE ACCESS

2012 Volume 76 Issue 6 Pages 1233-1235

DOI https://doi.org/10.1271/bbb.110994

View "Advance Publication" version (June 7, 2012).

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Abstract

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

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