Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Notes
6'-Hydroxyoxosorbicillinol, a New Lipoxygenase Inhibitor and PGD2/LTB4 Release Suppressor from Penicillium sp.
Toshikazu KOMODAMasazumi NISHIKAWA
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JOURNAL FREE ACCESS

2012 Volume 76 Issue 7 Pages 1404-1406

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Abstract

A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C14H16O6), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C14H16O5), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC50, 16 µM) than 2 (IC50, 150 µM), and also showed prostaglandin D2 (PGD2) and leucotriene B4 (LTB4) release suppression activity (IC50, 10 µM for PGD2 and 100 µM for LTB4).

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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