Specific 5-Hydroxylation of Piperlongumine by Beauveria bassiana ATCC 7159

Jiachen ZI; S. Gabrielle GLADSTONE; Jixun ZHAN

doi:10.1271/bbb.120223

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Notes

Specific 5-Hydroxylation of Piperlongumine by Beauveria bassiana ATCC 7159

Jiachen ZI, S. Gabrielle GLADSTONE, Jixun ZHAN

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Keywords: anti-cancer, Beauveria bassiana ATCC 7159, biotransformation, hydroxylation, piperlongumine

JOURNAL FREE ACCESS

2012 Volume 76 Issue 8 Pages 1565-1567

DOI https://doi.org/10.1271/bbb.120223

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Abstract

A new hydroxylated derivative was efficiently prepared by transforming the natural anti-cancer product, piperlongumine, with Beauveria bassiana ATCC 7159. Its structure was determined to be 5-hydroxylpiperlongumine on the basis of the spectroscopic data. The absolute configuration at C-5 was established as R by Mosher's method.

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