Physiological Effects and Tissue Distribution from Large Doses of Tocotrienol in Rats

Akira SHIBATA; Kiyotaka NAKAGAWA; Hitoshi SHIRAKAWA; Teiko KOBAYASHI; Yuki KAWAKAMI; Rie TAKASHIMA; Ai OHASHI; Shoko SATO; Yusuke OHSAKI; Fumiko KIMURA; Toshiyuki KIMURA; Tsuyoshi TSUDUKI; Michio KOMAI; Teruo MIYAZAWA

doi:10.1271/bbb.120387

Food & Nutrition Science Notes

Physiological Effects and Tissue Distribution from Large Doses of Tocotrienol in Rats

Akira SHIBATA, Kiyotaka NAKAGAWA, Hitoshi SHIRAKAWA, Teiko KOBAYASHI, Yuki KAWAKAMI, Rie TAKASHIMA, Ai OHASHI, Shoko SATO, Yusuke OHSAKI, Fumiko KIMURA, Toshiyuki KIMURA, Tsuyoshi TSUDUKI, Michio KOMAI, Teruo MIYAZAWA

Author information

Akira SHIBATA
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
Kiyotaka NAKAGAWA
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
Hitoshi SHIRAKAWA
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Teiko KOBAYASHI
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
Yuki KAWAKAMI
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University
Rie TAKASHIMA
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Ai OHASHI
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Shoko SATO
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Yusuke OHSAKI
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Fumiko KIMURA
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
Toshiyuki KIMURA
National Agricultural Research Center for Tohoku Region
Tsuyoshi TSUDUKI
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
Michio KOMAI
Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Teruo MIYAZAWA
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

Keywords: tocotrienol, tocopherol, large dose, tissue distribution, rat

JOURNAL FREE ACCESS

2012 Volume 76 Issue 9 Pages 1805-1808

DOI https://doi.org/10.1271/bbb.120387

View "Advance Publication" version (September 7, 2012).

Details

Abstract

Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.

Corresponding author

Register with J-STAGE for free!