Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
MurA as a Primary Target of Tulipalin B and 6-Tuliposide B
Kengo SHIGETOMISanne Harder OLESENYan YANGShinya MITSUHASHIErnst SCHÖNBRUNNMakoto UBUKATA
Author information
Keywords: tuliposide, tulipalin, MurA
JOURNALS FREE ACCESS
Supplementary material

2013 Volume 77 Issue 12 Pages 2517-2519

Details
Abstract

(−)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.

Information related to the author

This article cannot obtain the latest cited-by information.

© 2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
Previous article Next article
feedback
Top