ManR, a Transcriptional Regulator of the β-Mannan Utilization System, Controls the Cellulose Utilization System in Aspergillus oryzae

Masahiro OGAWA; Tetsuo KOBAYASHI; Yasuji KOYAMA

doi:10.1271/bbb.120795

Biochemistry & Molecular Biology Communications

ManR, a Transcriptional Regulator of the β-Mannan Utilization System, Controls the Cellulose Utilization System in Aspergillus oryzae

Masahiro OGAWA, Tetsuo KOBAYASHI, Yasuji KOYAMA

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Keywords: Aspergillus oryzae, transcriptional regulator, ManR, cellulose utilization system, hemicellulose utilization system

JOURNAL FREE ACCESS

2013 Volume 77 Issue 2 Pages 426-429

DOI https://doi.org/10.1271/bbb.120795

View "Advance Publication" version (February 7, 2013).

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Abstract

ManR, a DNA-binding protein possessing the Zn(II)₂Cys₆ binuclear cluster domain, acts as a positive regulator of mannanolytic enzyme genes in Aspergillus oryzae. In this study, we found that ManR controlled the expression not only of mannanolytic enzyme genes but also of cellulolytic enzyme genes in A. oryzae, based on DNA microarray analysis of a manR-disruptant and a manR-overexpressing strain. A new model for the regulation of cellulase and hemicellulase genes mediated by ManR and XlnR in A. oryzae is proposed.

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