Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Abstract

This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitrite, inhibitory activity against DNA polymerases, and cytotoxicity in cancer cells.