Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Manami KURISU; Yusaku MIYAMAE; Kazuma MURAKAMI; Junkyu HAN; Hiroko ISODA; Kazuhiro IRIE; Hideyuki SHIGEMORI

doi:10.1271/bbb.130101

Organic Chemistry Notes

Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Manami KURISU, Yusaku MIYAMAE, Kazuma MURAKAMI, Junkyu HAN, Hiroko ISODA, Kazuhiro IRIE, Hideyuki SHIGEMORI

Author information

Keywords: acteoside, amyloid β, aggregation, Alzheimer's disease, phenylethanoid glycoside

JOURNAL FREE ACCESS

2013 Volume 77 Issue 6 Pages 1329-1332

DOI https://doi.org/10.1271/bbb.130101

View "Advance Publication" version (June 7, 2013).

Details

Abstract

We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

Corresponding author

Register with J-STAGE for free!