Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

Kazuhisa HONDA; Takaoki SANEYASU; Shin HASEGAWA; Yuji TOMINAGA; Shinichi YOKOTA; Hiroshi KAMISOYAMA

doi:10.1271/bbb.130104

Food & Nutrition Science Notes

Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

Kazuhisa HONDA, Takaoki SANEYASU, Shin HASEGAWA, Yuji TOMINAGA, Shinichi YOKOTA, Hiroshi KAMISOYAMA

Author information

Keywords: hydroxymethylglutaryl-CoA (HMG-CoA), cholesterol 7α-hydroxylase (CYP7A1), cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL)

JOURNAL FREE ACCESS

2013 Volume 77 Issue 6 Pages 1326-1328

DOI https://doi.org/10.1271/bbb.130104

View "Advance Publication" version (June 7, 2013).

Details

Abstract

Dietary licorice fravonoid oil (LFO) significantly decreased hepatic cholesterol and plasma lipoprotein cholesterol levels in high-fat diet rats. It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. The low density lipoprotein receptor mRNA level was significantly increased by LFO. These results suggest that dietary LFO improves cholesterol metabolism in obese animals.

Corresponding author

Register with J-STAGE for free!