Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

Kazuhisa HONDA; Takaoki SANEYASU; Shin HASEGAWA; Yuji TOMINAGA; Shinichi YOKOTA; Hiroshi KAMISOYAMA

doi:10.1271/bbb.130104

Food & Nutrition Science Notes

Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

Kazuhisa HONDA, Takaoki SANEYASU, Shin HASEGAWA, Yuji TOMINAGA, Shinichi YOKOTA, Hiroshi KAMISOYAMA

著者情報

キーワード: hydroxymethylglutaryl-CoA (HMG-CoA), cholesterol 7α-hydroxylase (CYP7A1), cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL)

ジャーナルフリー

2013 年 77 巻 6 号 p. 1326-1328

DOI https://doi.org/10.1271/bbb.130104

View "Advance Publication" version (June 7, 2013).

詳細

抄録

Dietary licorice fravonoid oil (LFO) significantly decreased hepatic cholesterol and plasma lipoprotein cholesterol levels in high-fat diet rats. It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. The low density lipoprotein receptor mRNA level was significantly increased by LFO. These results suggest that dietary LFO improves cholesterol metabolism in obese animals.

責任著者(Corresponding author)

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