Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids

Ayako AOKI-YOSHIDA; Kasumi ICHIDA; Reiji AOKI; Toshiyuki KAWASUMI; Chise SUZUKI; Yoshiharu TAKAYAMA

doi:10.1271/bbb.120979

Organic Chemistry Notes

Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids

Ayako AOKI-YOSHIDA, Kasumi ICHIDA, Reiji AOKI, Toshiyuki KAWASUMI, Chise SUZUKI, Yoshiharu TAKAYAMA

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Keywords: aromatic amino acid, 4-hydroxyphenyllactic acid, indole-3-lactic acid, interleukin-6 (IL-6), keratinocyte

JOURNAL FREE ACCESS

2013 Volume 77 Issue 8 Pages 1766-1768

DOI https://doi.org/10.1271/bbb.120979

View "Advance Publication" version (August 7, 2013).

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Abstract

The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.

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