Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI; Mariko SEKIGUCHI; Tomomi SHIRAI; Mami YAMADA; Yoshiko ISHIMI

doi:10.1271/bbb.130290

Biochemistry & Molecular Biology Notes

Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI, Mariko SEKIGUCHI, Tomomi SHIRAI, Mami YAMADA, Yoshiko ISHIMI

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Keywords: retinol binding protein 4 (RBP4), proteasome subunit beta type 1 (PSMB1), insulin resistance, nuclear localization, transcription

JOURNAL FREE ACCESS

2013 Volume 77 Issue 8 Pages 1785-1787

DOI https://doi.org/10.1271/bbb.130290

View "Advance Publication" version (August 7, 2013).

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Abstract

The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

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