Regulation of the Basolateral Na⁺, K⁺-ATPase in the Activation of Electrogenic Na⁺ Absorption Induced by Isoproterenol in the Rat Distal Colon

Abstract

We investigated the effects of cAMP on the basolateral Na⁺, K⁺-ATPase and apical amiloride-sensitive Na⁺ channel in the rat distal colon. Under mucosal treatment with nystatin, isoproterenol and forskolin increased the basolateral Na⁺ pump current. Under serosal treatment with ouabain, both agents slightly increased the amiloride-sensitive Na current, but not to a significant level. We concluded that cAMP activates the basolateral Na⁺, K⁺-ATPase in the rat distal colon.