Activation of the hTAS2R14 Human Bitter-Taste Receptor by (−)-Epigallocatechin Gallate and (−)-Epicatechin Gallate

Toyomi YAMAZAKI; Masataka NARUKAWA; Mineko MOCHIZUKI; Takumi MISAKA; Tatsuo WATANABE

doi:10.1271/bbb.130329

Food & Nutrition Science Notes

Activation of the hTAS2R14 Human Bitter-Taste Receptor by (−)-Epigallocatechin Gallate and (−)-Epicatechin Gallate

Toyomi YAMAZAKI, Masataka NARUKAWA, Mineko MOCHIZUKI, Takumi MISAKA, Tatsuo WATANABE

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Keywords: green tea, catechin, bitter taste, bitter taste receptor, hTAS2R14

JOURNAL FREE ACCESS

2013 Volume 77 Issue 9 Pages 1981-1983

DOI https://doi.org/10.1271/bbb.130329

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Abstract

Tea catechins have strong bitterness and influence the taste of tea. Among the 25 human bitter-taste receptors (TAS2Rs), we found that hTAS2R14 responded to catechins, in addition to hTAS2R39, a known catechin receptor. Although hTAS2R14 responded to (−)-epicatechin gallate and (−)-epigallocatechin gallate, it did not respond to (−)-epicatechin and (−)-epigallocatechin.

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