Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea

Yuh-Hwa LIU; Wen-Chun WU; Yeh-Lin LU; Ying-Jang LAI; Wen-Chi HOU

doi:10.1271/bbb.100096

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Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea

Yuh-Hwa LIU, Wen-Chun WU, Yeh-Lin LU, Ying-Jang LAI, Wen-Chi HOU

著者情報

キーワード: antioxidant activity, hydroxyurea (HU), monoamine oxidase (MAO), semicarbazide-sensitive amine oxidase (SSAO)

ジャーナルフリー早期公開

論文ID: 100096

DOI https://doi.org/10.1271/bbb.100096

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 6 p.1256

詳細

抄録

Hydroxyurea (HU, NH₂CONHOH), or hydroxycarbamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicarbazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

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