Department of Applied Bio-Science, Tokyo University of Agriculture Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Arata YAJIMA
Department of Applied Bio-Science, Tokyo University of Agriculture
Ken ISHIGAMI
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tomoo NUKADA
Department of Applied Bio-Science, Tokyo University of Agriculture
Hidenori WATANABE
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Short-step syntheses of (2RS,8R,10R)-YM-193221 (1) and tyroscherin (2), which are biologically active compounds isolated from Pseudallescheria sp., were accomplished in six and eight steps from L-tyrosine. The relative stereochemistry of natural YM-193221 was determined to be 8R*,10R*.
