Identification of a Spatio-Temporal Enhancer Element for the Alzheimer’s Amyloid Precursor Protein-Like-1 Gene in the Nematode Caenorhabditis elegans

Ryusuke NIWA; Kazumasa HADA

doi:10.1271/bbb.100450

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Identification of a Spatio-Temporal Enhancer Element for the Alzheimer’s Amyloid Precursor Protein-Like-1 Gene in the Nematode Caenorhabditis elegans

Ryusuke NIWA, Kazumasa HADA

著者情報

キーワード: Caenorhabditis elegans, heterochronic gene, nhr-25, nuclear receptor

ジャーナルフリー早期公開

論文ID: 100450

DOI https://doi.org/10.1271/bbb.100450

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 12 p.2497

詳細

抄録

During the larva-to-adult transition of the nematode Caenorhabditis elegans, expression of the Alzheimer’s amyloid precursor protein-like gene, apl-1, is temporally regulated in seam cells. This regulation requires several transcription factors, including nuclear receptor NHR-25. Here we describe a critical cis-regulatory element of apl-1 transcription. The element is conserved among Caenorhabditis sister species and is similar to nuclear receptor binding consensus.

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