Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Tohru SAKAI; Sakina FUROKU; Mariko NAKAMOTO; Emi SHUTO; Toshio HOSAKA; Yasuhiko NISHIOKA; Saburo SONE

doi:10.1271/bbb.100710

This article has now been updated. Please use the final version.

Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Tohru SAKAI, Sakina FUROKU, Mariko NAKAMOTO, Emi SHUTO, Toshio HOSAKA, Yasuhiko NISHIOKA, Saburo SONE

Author information

Tohru SAKAI
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Sakina FUROKU
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Mariko NAKAMOTO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Emi SHUTO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Toshio HOSAKA
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Yasuhiko NISHIOKA
Department of Respiratory Medicine and Rheumatology, Institute for Health Biosciences, The University of Tokushima
Saburo SONE
Department of Respiratory Medicine and Rheumatology, Institute for Health Biosciences, The University of Tokushima

Keywords: soy isoflavone, equol, colitis, IL-10, inflammation

JOURNAL FREE ACCESS Advance online publication

Article ID: 100710

DOI https://doi.org/10.1271/bbb.100710

The final version of this article is now available: Vol. 75 (2011) , No. 3 p.593

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Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

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