Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Tohru SAKAI; Sakina FUROKU; Mariko NAKAMOTO; Emi SHUTO; Toshio HOSAKA; Yasuhiko NISHIOKA; Saburo SONE

doi:10.1271/bbb.100710

Tohru SAKAI, Sakina FUROKU, Mariko NAKAMOTO, Emi SHUTO, Toshio HOSAKA, Yasuhiko NISHIOKA, Saburo SONE

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Keywords: soy isoflavone, equol, colitis, IL-10, inflammation

JOURNALS FREE ACCESS Advance online publication

Article ID: 100710

DOI https://doi.org/10.1271/bbb.100710

The final version of this article with its full bibliographical information is available. To access the article, click here (Vol. 75 (2011) , No. 3 p.593).

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Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

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