Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice
Tohru SAKAISakina FUROKUMariko NAKAMOTOEmi SHUTOToshio HOSAKAYasuhiko NISHIOKASaburo SONE
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JOURNALS FREE ACCESS Advance online publication

Article ID: 100710

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Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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