Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Tohru SAKAI; Sakina FUROKU; Mariko NAKAMOTO; Emi SHUTO; Toshio HOSAKA; Yasuhiko NISHIOKA; Saburo SONE

doi:10.1271/bbb.100710

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Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Tohru SAKAI, Sakina FUROKU, Mariko NAKAMOTO, Emi SHUTO, Toshio HOSAKA, Yasuhiko NISHIOKA, Saburo SONE

著者情報

キーワード: soy isoflavone, equol, colitis, IL-10, inflammation

ジャーナルフリー早期公開

論文ID: 100710

DOI https://doi.org/10.1271/bbb.100710

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 3 p.593

詳細

抄録

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

責任著者(Corresponding author)

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