Suppression of Oral Tolerance by Lactococcus lactis in Mice

Tohru SAKAI; Yuko HIROTA; Mariko NAKAMOYO; Emi SHUTO; Toshio HOSAKA; Seiya MAKINO; Shuji IKEGAMI

doi:10.1271/bbb.100714

Suppression of Oral Tolerance by Lactococcus lactis in Mice

Tohru SAKAI, Yuko HIROTA, Mariko NAKAMOYO, Emi SHUTO, Toshio HOSAKA, Seiya MAKINO, Shuji IKEGAMI

Author information

Tohru SAKAI
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Yuko HIROTA
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Mariko NAKAMOYO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Emi SHUTO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Toshio HOSAKA
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Seiya MAKINO
Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Dairies Corporation
Shuji IKEGAMI
Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Dairies Corporation

Keywords: Lactococcus lactis, oral tolerance, ovalbumin, casein, NC/Nga mice

JOURNALS FREE ACCESS Advance online publication

Article ID: 100714

DOI https://doi.org/10.1271/bbb.100714

The final version of this article with its full bibliographical information is available. To access the article, click here (Vol. 75 (2011) , No. 3 p.599).

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Abstract

Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4⁺CD25⁺ cells was increased in DO11.10 mice orally given OVA, but this increase of CD4⁺CD25⁺ cells were suppressed in L. lactis-fed DO11.10 mice.

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