Long-Term Cultured Human Skin Mast Cells Are Suitable for Pharmacological Studies of Anti-Allergic Drugs Due to High Responsiveness to FcεRI Cross-Linking

Sven GUHL; Metin ARTUC; Angelos NEOU; Magda BABINA; Torsten ZUBERBIER

doi:10.1271/bbb.100745

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Long-Term Cultured Human Skin Mast Cells Are Suitable for Pharmacological Studies of Anti-Allergic Drugs Due to High Responsiveness to FcεRI Cross-Linking

Sven GUHL, Metin ARTUC, Angelos NEOU, Magda BABINA, Torsten ZUBERBIER

著者情報

キーワード: mast cells, allergy, IgE receptor, drug testing

ジャーナルフリー早期公開

論文ID: 100745

DOI https://doi.org/10.1271/bbb.100745

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 2 p.382

詳細

抄録

Human skin mast cells proliferated in the presence of interleukin (IL)-4+SCF (expanding 18-fold in 8 weeks) and acquired profound responsiveness towards high affinity IgE receptor (FcεRI) cross-linking, liberating about 75% of their histamine. In a proof-of-concept, we found that these cells are useful for pharmacological testing. Even a subtle inhibition of degranulation can be visualized. This model might prove valuable in tests of novel anti-allergic drugs.

責任著者(Corresponding author)

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