Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Yuji NAKAI; Bunpei SATO; Shota USHIAMA; Shinji OKADA; Keiko ABE; Soichi ARAI

doi:10.1271/bbb.100819

This article has now been updated. Please use the final version.

Hepatic Oxidoreduction-Related Genes Are Upregulated by Administration of Hydrogen-Saturated Drinking Water

Yuji NAKAI, Bunpei SATO, Shota USHIAMA, Shinji OKADA, Keiko ABE, Soichi ARAI

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Keywords: hydrogen-saturated water, DNA microarray, rat, liver, oxidation-reduction

JOURNAL FREE ACCESS Advance online publication

Article ID: 100819

DOI https://doi.org/10.1271/bbb.100819

The final version of this article is now available: Vol. 75 (2011) , No. 4 p.774

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Abstract

The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.

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