Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU; Ping GUO; Cuizhou LIU; Zhanping SUN; Liping GUI; Yuanqiang GUO; Tohru YAMAKUNI; Yasushi OHIZUMI

doi:10.1271/bbb.110146

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Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU, Ping GUO, Cuizhou LIU, Zhanping SUN, Liping GUI, Yuanqiang GUO, Tohru YAMAKUNI, Yasushi OHIZUMI

著者情報

キーワード: Fritillaria ebeiensis, dietrpenoids, kaurane, neuroprotective effect

ジャーナルフリー早期公開

論文ID: 110146

DOI https://doi.org/10.1271/bbb.110146

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 7 p.1386

詳細

抄録

The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

責任著者(Corresponding author)

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