Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

Yoshimi YAMAKAMI; Kensuke MIKI; Morio ENDOH; Ryuzo YONEKURA; Ryo UKEKAWA; Yusuke KOBAYASHI; Michihiko FUJII; Dai AYUSAWA

doi:10.1271/bbb.110179

This article has now been updated. Please use the final version.

Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

Yoshimi YAMAKAMI, Kensuke MIKI, Morio ENDOH, Ryuzo YONEKURA, Ryo UKEKAWA, Yusuke KOBAYASHI, Michihiko FUJII, Dai AYUSAWA

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Keywords: human cells, cytotoxicity, detergent, cosmetics, senescence

JOURNAL FREE ACCESS Advance online publication

Article ID: 110179

DOI https://doi.org/10.1271/bbb.110179

The final version of this article is now available: Vol. 75 (2011) , No. 7 p.1395

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Abstract

We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The cytotoxicity of commercial washing products was determined mainly by the contents of surfactants. All of them induced premature senescence in normal cells, but not in tumor-derived or immortalized cells, under sublethal conditions. Residual surfactants might be a risk factor for skin aging.

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