Alteration of Ethanol Tolerance Caused by the Deficiency in the Genes Associated with Histone Deacetylase Complex in Budding Yeast

Takao MATSUDA; Shuki FUJIMURA; Hiroshi SUDA; Yoshimi MATSUFUJI; Junichi NAKAGAWA

doi:10.1271/bbb.110232

This article has now been updated. Please use the final version.

Alteration of Ethanol Tolerance Caused by the Deficiency in the Genes Associated with Histone Deacetylase Complex in Budding Yeast

Takao MATSUDA, Shuki FUJIMURA, Hiroshi SUDA, Yoshimi MATSUFUJI, Junichi NAKAGAWA

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Keywords: Saccharomyces cerevisiae, epigenetic gene regulation, ethanol tolerance, stress response, histone deacetylase

JOURNAL FREE ACCESS Advance online publication

Article ID: 110232

DOI https://doi.org/10.1271/bbb.110232

The final version of this article is now available: Vol. 75 (2011) , No. 9 p.1829

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Abstract

Upon exposure to 8% ethanol, survival and growth of yeast strains deficient in histone deacetylase complex genes was examined. Of the 18 mutants tested, the Δsir3 and Δsir4 strains showed higher resistance to ethanol, while the Δrco1, Δhos3, Δhda2, and Δhst1 strains were more sensitive than the wild type. Furthermore, these ethanol-resistant patterns varied under aerobic and anaerobic culture conditions.

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