Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow, Achillea millefolium

Yong LI; Man-Li ZHANG; Bin CONG; Si-Ming WANG; Mei DONG; Françoise SAURIOL; Chang-Hong HUO; Qing-Wen SHI; Yu-Cheng GU; Hiromasa KIYOTA

doi:10.1271/bbb.110234

This article has now been updated. Please use the final version.

Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow, Achillea millefolium

Yong LI, Man-Li ZHANG, Bin CONG, Si-Ming WANG, Mei DONG, Françoise SAURIOL, Chang-Hong HUO, Qing-Wen SHI, Yu-Cheng GU, Hiromasa KIYOTA

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Keywords: Achillea millefolium, flower, guaianolide, isolation

JOURNAL FREE ACCESS Advance online publication

Article ID: 110234

DOI https://doi.org/10.1271/bbb.110234

The final version of this article is now available: Vol. 75 (2011) , No. 8 p.1554

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Abstract

Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC₅₀) values of 5.8, 10 and 0.31 μM, respectively.

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