Calreticulin Inhibits Prion Protein PrP-(23–98) Aggregation in Vitro

Noriyuki SHIRAISHI; Yoko INAI; Yoshiaki HIRANO; Yoshito IHARA

doi:10.1271/bbb.110287

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Calreticulin Inhibits Prion Protein PrP-(23–98) Aggregation in Vitro

Noriyuki SHIRAISHI, Yoko INAI, Yoshiaki HIRANO, Yoshito IHARA

著者情報

キーワード: prion protein, PrP-(23–98), aggregates, calreticulin

ジャーナルフリー早期公開

論文ID: 110287

DOI https://doi.org/10.1271/bbb.110287

この記事には本公開記事があります。

The final version of this article is now available: Vol. 75 (2011) , No. 8 p.1625

詳細

抄録

Because prion protein PrP-(23–98) was recently found to polymerize into amyloid-like and proteinase K-resistant spherical aggregates in the presence of NADPH plus copper ions, we tested to determine whether calreticulin (CRT) inhibits PrP-(23–98) aggregation in vitro. The results indicated that CRT suppressed PrP-(23–98) aggregation, and that CRT-mediated solubilization occurred in the aggregates.

責任著者(Corresponding author)

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